New Study Suggests Metabolic Homeostasis As A Novel Opportunity In The Treatment of Diseases Such As Diabetes (amazon) (shopzilla)

Miami, Florida (PRWEB) January 21, 2012

Nutri-Med Logic Corp expands on a new study, published in the January Issue of the World Journal of Diabetes, which has targeted a gene (Nrf2), a central regulator of the cellular antioxidant defense, as a novel target for the treatment of Diabetes.

Nrf2 produces the most potent internal anti-oxidant, that being glutathione and while glutathione is found in food but studies have shown its concentration does not increase, significantly, through conventional food or its dietary supplementation.

Additionally, glutathione decreases by age and lack of glutathione shifts the bodys homeostasis toward oxidative stress, which according to this study, oxidative stress, may lead to the pathogenesis of diabetes, cardiovascular diseases, metabolic syndrome, aging and cancer.

Proper nutrients play an important role in enhancing or moderating the factors that shift the bodys homeostasis.

In 2004, a panel of U.S. and Canadian scientists recalculated the amounts of vitamins and minerals, based age and sex, and declared 30 vitamins and minerals as the raw materials that body requires daily but it cannot make in sufficient amounts: Essential Nutrients.

It is a fact that lack of these 30 essential nutrients plays an important part in the homeostasis of the body and some of those present important anti-oxidant properties. However, none of these 30 essential nutrients would increase the levels of glutathione, the most potent endogenous anti-oxidant, which recycles vitamin C and E, as well as re-energizing Co-Enzyme Q-10, an important anti-oxidant for the heart.

In 1996, Professor Lester Packer a senior anti-oxidant researcher and scientist at the University of California (Berkley) discovered that dietary supplementation of R-Alpha Lipoic Acid (also known as R-Lipoic Acid), increased the production, as well as the cellular concentration of glutathione. R-Alpha Lipoic, in its reduced form, is made by the human body, as a vital co-enzyme in the metabolism of glucose.

Stress and inflammation, also, play an equal but crucial role in shifting the bodys homeostasis and are implicated in diseases, ranging from degenerative, neurodegenerative, chronic, autoimmune to opportunistic and infectious diseases.

A cursory search of PubMed records reveals at least 200,000 related studies in the role of stress or inflammation and diseases, as well as, at least 2,100 related studies of Omega-3 fatty acids in inflammation and stress.

The primary mechanism for the resolution of the inflammation starts from the cellular membrane through the derivatives of the fatty acids of Omega-3. The membrane ratio of Omeg-3 dictates the intensity and the duration of inflammatory responses.

Diets lacking Omega-3 tilt the balance to the pro-inflammatory agents, thus throwing the body out of its homeostasis, as well.

The role of stress and homeostasis has been well studied and established. More importantly, the role of Omega-3 in moderating stress, specifically in the cases of depression and anxiety, has been even suggested by The National Institutes of Health.

The human body needs Omega-3 but cannot produce it. In the scientific community, Omega-3 is referred to as Essential Fatty Acids.

In conclusion, Nutri-Med Logic Corp agrees with this recent study and the consequences of a redox imbalance but adds that stress and inflammation, also, play a crucial role in the homeostasis of the human body. Nutri-Med Logic Corp adds that the foregoing clearly establishes the need for inclusion of an anti-oxidant and an anti-inflammatory nutrient in the daily diet.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Pharmaceutical Grade R-Alpha Lipoic Acid, the ideal daily anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for more than 40 years.

Nutri-Med Logic Corp is also producer of a Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years;

Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

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    New Study on Oxidative Stress Provides Insights to Premature Aging, Diabetes, Atherosclerosis, Hypertension and Neurodegenerative Diseases (amazon) (shopzilla)

    Miami, FL (PRWEB) February 17, 2012

    A newly published study, adopting the thinning of skin layers as a measure of normal or premature aging and the development of degenerative disease, states that in animal models proper anti-oxidant defense lead to normal skin aging, whereas deficiency in the anti-oxidant defense resulted in premature aging. Nutri-Med Logic Corp adds that an imbalance in the anti-oxidant defense inevitably involves the immune system and, thus, shifting its homeostasis. Accordingly, any therapeutic intervention needs to incorporate anti-inflammatory nutrients, as well.

    According the study, at ideal levels, ROS play essential roles as regulatory mediators in signaling or defense processes, including the promotion of angiogenesis (blood vessel formation), erythropoietin (red blood cell) production and the destruction of bacteria and other foreign substances by immune system.

    ROS is regulated by cellular anti-oxidant defense system, one of which is Superoxide Dismutase (SOD). Lower cellular levels of SOD gives rise to excessive Reactive Oxygen Species concentration. In another word, development of oxidative stress and according to this study, a growing body of evidence suggests its definitive role in premature aging and a host of human diseases ranging from diabetes, atherosclerosis, hypertension, cardiovascular diseases, neurodegenerative diseases up to cancer (DNA damage).

    Nutri-Med Logic Corp states that while increasing SOD might not be effectively attainable through diet, but the concentration of an equally important internal anti-oxidant, R-Alpha Lipoic, could very well be attained through its dietary supplementation.

    Both R-Alpha Lipoic and SOD are found in the mitochondria, where metabolism of glucose gives rise to the production of Reactive Oxygen Species.

    Application of R-Alpha Lipoic has conclusively shown that in presence of R-Alpha Lipoic, there is reduced requirement for SOD, by the human body, indicating the importance of R-Alpha Lipoic as a key anti-oxidant nutrient. (1)

    Other studies have shown that SOD presents anti-inflammatory properties, more specifically in studies relating to inflammatory Bowel Disease. (2)

    Inflammation is an immune mechanism and its dysregulation is not limited to Inflammatory Bowel Disease, rather it is implicated in the same spectrum of diseases as the oxidative stress, including but limited to per-mature cellular aging, diabetes, atherosclerosis, hypertension, cardiovascular diseases, neurodegenerative diseases up to cancer.

    While SOD has anti-inflammatory properties but it is not the mechanism, by which the human body resolves the inflammation. The human body resolves inflammation in two principal manners, one of which is through derivatives of Omega-3 fatty acids. The human body is incapable of producing Omega-3, thus it must be supplied through diet.

    While addition of R-Alpha Lipoic is a valuable nutritional support in improving the anti-oxidant defense (redox homeostasis), contemporaneous incorporation of the most powerful anti-inflammatory nutrient (Omega-3) would improve the homeostasis of the immune system (inflammation).

    In conclusion, Nutri-Med Logic Corp agrees with this important new study but adds that regulation of inflammation is equally as important, in opposing the development of age-related disease and cellular premature aging, as the regulated anti-oxidant defense.

    Nutri-Med Logic Corp. is a producer dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years;

    Nutri-Med Logic Corp is also the producer of the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

    Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

    Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on the potential benefits of R-Alpha Lipoic and benefits of Omega-3 anti-inflammatory nutrient and What Is Omega-3 Good For.

    Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

    It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to treatment or cure.

    (1) J Brachial Plex Peripher Nerve Inj. 2010; 5: 15

    (2) J Leukoc Biol. 2004 Sep;76(3):537-44

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    Find More Anti Aging Dietary Supplements Press Releases

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      Improving the Regulation of Energy Expenditure May Reduce the Risk of Cardiovascular Diseases and Avoid Pre-Mature Cellular Aging (amazon) (shopzilla)

      Miami, FL (PRWEB) February 28, 2012

      A newly published study suggests, in animal models, an increased activity (expression) of a regulator of metabolism, PGC-1 Alpha, may improve pre-mature cellular aging. Nutri-Med Logic Corp, agreeing with this notable study, adds that credible research and evidence has pointed to R-Alpha Lipoic, a nutrient and a vital co-enzyme in the production of energy, as a viable mean to improve the activities of this regulator.

      According to this study, by Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL, aging increases our vulnerability to muscle degeneration (Sarcopenia), as well as cardiovascular diseases and that the accumulated alteration (mutation) in mitochondrial (cellular energy plant) DNA caused its dysfunction leading to potentially shorter lifespan.

      According to the University of Miami study, the increased expression of PGC-1 Alpha, a regulator of metabolism, while improved the mitochondrial function but did not reverse the accumulated mutation in mitochondrial DNA, rather it caused a small increase in its mutation. Nonetheless, the increased expression of muscle PGC-1 Alpha improved some premature aging phenotypes.

      Suffices to say that increasing the function or capacity of mitochondria (biogenesis) results in the production of additional reactive oxygen species (oxidative stress) and the increased oxidative stress would be a contributing factor for the added mutation, in the abundance of mitochondria, as well as the copy number and integrity of mitochondrial DNA in human cells. (1)

      Amongst mitochondrial anti-oxidant molecules, mitochondrial glutathione not only acts as key anti-oxidant defense against reactive oxygen species but also acts as a detoxifying enzyme, counteracting a variety of free radicals such as hydrogen peroxide, lipid hydroperoxides and xenobiotics, as well as being a co-factor for enzymes glutathione peroxidase or glutathione-S-transferase. (2)

      In addition and according to The Department of Internal Medicine of University of Miami, the cellular Reduction-Oxidation (redox) is regulated by three systems, two of which are also regulated by glutathione. (3)

      Overwhelming number of institutes, including the prestigious Linus Pauling Institute, have determined that Lipoic Acid (also known as R-Alpha Lipoic Acid) increases the synthesis of glutathione in the human cells.

      Moreover and according to USDA/ARS Childrens Nutrition Research Center, in aged animals, the metabolic action of R-Alpha Lipoic is mediated through activating a cellular energy sensor (AMPK) that can regulate PGC-1 Alpha, a metabolic regulator. (4)

      The USDA/ARS study suggests that, in animal studies, R-Alpha Lipoic Acid improves skeletal muscle energy metabolism (PGC-1 Alpha).

      In conclusion, Nutri-Med Logic Corp agrees with this study and adds that R-Alpha Lipoic Acid, a nutrient and a vital co-enzyme in the production of cellular energy, offers unique health benefits such as being a potent anti-oxidant by itself, increasing the glutathione levels and most importantly improving the energy homeostasis.

      Nutri-Med Logic Corp is a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, a potent anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades.

      Nutri-Med Logic Corp is also the producer of the Natural, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

      Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

      Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on other potential benefits of R-Alpha Lipoic Acid and anti-inflammatory nutrients such as Omega-3 and What Is Omega-3.

      Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

      It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

      1. Int J Biochem Cell Biol. 2005 Apr;37(4):822-34.

      2. Antioxidants & Redox Signaling, Volume 11, Number 11, 2009

      3. Drugs. 2011 Jul 30;71(11):1385-96

      4. Metabolism. 2010 July; 59(7): 967976.

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        Dr. J G Moellendorf Offers 6 Dietary and Alternative Therapy Tips to Reduce the Risk of Alzheimer?s and Parkinson?s Diseases (amazon) (shopzilla)

        Sturgeon Bay, WI (PRWEB) November 06, 2012

        Over 5.4 million Americans are affected by Alzheimer?s disease. The incidence doubles with every 5 years beyond age 65. An additional 1.5 million people are affected by Parkinson?s, along with nearly 1 million with other dementias. Sturgeon Bay, Wisconsin Chiropractor and Naturopath, Dr. J G Moellendorf, DC, ND, LCP notes that this has a huge financial cost on society for treatment and nursing home care, along with the emotional toll on the victim and his or her family. These tragic diseases threaten to bankrupt not only the family, but the nation itself.

        There are many genetic and environmental risks that lead to Alzheimer?s, Parkinson?s and the other dementias, but early recognition and natural preventative measures have been shown to delay and even halt their progression. Following are 6 tips that can be used to reduce the risks of dementias based on research from the past few years.

        1) Increase vitamin D

        Macrophages need to remove amyloid-? protein from the brain to avoid tau entanglement formations according to research published in the March 2012 issue of the Journal of Alzheimer?s Disease, Volume 29, Number 1. This process is dependant on an adequate supply of vitamin D. While the minimum recommended daily allotment has recently been increased to 400 IU, this should probably be increased to 1000 to 2000 IU daily to achieve this purpose.

        2) Increase omega-3 consumption

        The increased consumption of omega-3 fatty acids not only reduced death by strokes and heart attacks by 19% to 45%, it reduced the risk of dementia by 40 to 50% according to research published in the December 2010 issue of Nutrition Reviews, Volume 68. In addition, the May 2, 2012 edition of Neurology reports that the consumption of omega-3s reduces the production of ?-amyloid proteins of Alzheimer?s by 37%. The safest form of omega-3s is from molecularly distilled cold water fish oil as most fish have become contaminated with mercury and dioxins from pollution. Most adults need to consume 2000 to 3000 milligrams per day of combined EPA and DHA.

        3) Take a quality, food-based multi-vitamin/mineral supplement

        Many vital nutrients are missing due to food processing and growing food in depleted soils. A quality supplement can help replace these lost nutrients.

        4) Keep active

        There is truth in the old adage: move it or lose it. Keeping active has been shown to slow the progression of dementia. This often becomes difficult in the elderly because they ?ache all over? or ?just don?t feel good?. Chronic stress on spinal joints from poor posture and old injuries leads to chronic inflammation, which can result in arthritis. As the spinal joints become stiffer and misaligned, they can also irritate the spinal nerves, causing other problems depending on what body systems the nerves control. Spinal adjustments by a Doctor of Chiropractic can increase the spinal movement, decrease the aches and pains, and allow the nerves to work properly.

        5) Cold laser

        Brain aging is related to the accumulation of inflammation, oxidative damage to the cells, reduced metabolism, and possibly mitochondrial failure. Those with Alzheimer?s show decreased levels of the enzymes superoxide dismutase and glutathione peroxidase in the plasma. This causes inadequate anti-oxidant enzymatic activity to counteract the production of free radicals in the cellular mitochondria. Research has shown that Low Level Laser Therapy(cold laser) increases the production of these critical enzymes.

        6) Lose the extra weight

        A study was published in Neurology on March 26, 2008 showing that central obesity (in the abdomen) during midlife increased the incidence of dementia by three times 30 years later. This dementia was independent of the increased cardiovascular and diabetes symptoms that also appeared. Obesity was defined as a caliper measurement from the front of the abdomen to the back exceeding 25 centimeters. Peripheral obesity (in the arms and legs) had no effect on the risk of dementia.

        Additional information about Chiropractic, Naturopathy, and other forms of natural health care has been provided by Moellendorf Chiropractic Office, Ltd. at http://www.all-about-wellness.com.

        About: Dr. J G Moellendorf, DC, ND, LCP

        Dr. J G Moellendorf, DC, ND, LCP attended the University of Wisconsin?Superior where he majored in Physics and Mathematics, with a minor in art photography. While attending the University of Minnesota?Minneapolis, he assisted in research on ribosomal proteins. Completing his Chiropractic studies at Palmer College of Chiropractic in Davenport, Iowa, he graduated Cum Laude (with high honors) in 1983. He started Moellendorf Chiropractic Office, Ltd. in Sturgeon Bay, Wisconsin in 1983. In 1996, Dr. Moellendorf was awarded his Doctorate in Naturopathy from Trinity School of Natural Health. In 2001, he received Chiropractic?s most prestigious award, the honorary Legion of Chiropractic Philosophers degree, for his thesis ?The Workings of Innate Intelligence in Obsessive/Compulsive and Addictive Behaviors.? This paper was chosen for publishing in the book Philosophic Contemplations vol. 2 in 2002. In June of 2012, Dr. Moellendorf authored his first book titled Healthcare?s Best Kept Secret. Dr. Moellendorf can be contacted by phone (920) 493-2126, fax (920) 743-1145, email jgmoellendorf (at) itol (dot) com, his website at http://www.all-about-wellness.com, or send a carrier pigeon to 44.84722N and 87.36416W.







        More Anti Ageing Supplements Press Releases

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          Six Tips from Dr. J G Moellendorf for Reducing the Risk of Alzheimer?s and Parkinson?s Diseases (amazon) (shopzilla)

          Sturgeon Bay, WI (PRWEB) October 30, 2012

          Alzheimer?s disease affects over 5.4 million Americans, with the incidence doubling every 5 years beyond age 65. Parkinson?s affects an additional 1.5 million people, along with nearly 1 million with other dementias. Sturgeon Bay, Wisconsin Chiropractor and Naturopath, Dr. J G Moellendorf, DC, ND, LCP notes that this has a huge financial cost on society for treatment and nursing home care, along with the emotional toll on the victim and his or her family. These tragic diseases threaten to bankrupt not only the family, but the nation itself.

          Many genetic and environmental risks lead to the dementias such as Alzheimer?s and Parkinson?s Diseases, but early recognition and natural preventative measures have been shown to delay and even halt their progression. Following are 6 tips to reduce the risks of dementias based on research from the past few years.

          1) Decrease (or eliminate) NSAIDs

          According to research published in the April 22, 2009 edition of Neurology, patients taking one NSAID daily (such as ibuprofen or naproxen) for at least 16 months, had a 66% increased risk of dementia, and a 57% increased risk of Alzheimer?s. While early studies suggested that NSAIDs may possibly delay the onset, they do not prevent and have no benefit in established dementias. The conclusion is that NSAIDs may reduce some of the chronic systemic inflammation that leads to dementia, but at the expense of liver and kidney damage. The reduction of inflammation is the key factor in decreasing the risk of getting Parkinson?s, Alzheimer?s, or the other dementias. This leads into the next several tips.

          2) Eliminate gluten consumption

          The gluten protein is difficult to digest. More than 40% of Caucasians have a genetic tendency toward gluten sensitivity, because they do not have the enzymes to fully break down gluten. As people age, enzyme production also decreases. The cytokines in the immune system then react to the undigested gluten amino acid chains as if they were bacterial invaders, resulting in inflammation. Avoidance of wheat, barley, and rye, such as in the Paleolithic diet, can stop this inflammatory process. Oats are often contaminated with wheat gluten in processing, and should be avoided unless guaranteed to be gluten free.

          3) Decrease copper intake

          The February 15, 2010 issue of Chemical Research in Toxicology pointed out that excessive copper becomes toxic to the cells by producing excess free radicals and inflammation. When rabbits were fed a diet to induce Alzheimer?s, the rabbits only did so when drinking tap water containing over 0.12 parts per million of copper, less than 10% the allowance of the Environmental Protection Agency. Since over 80% of American homes have copper pipes, alternatives such as reverse osmosis should be considered. Bottled water may or may not contain copper depending on its source. Since there is no copper deficiency in a balanced diet, multiple vitamin-mineral supplements containing copper may potentially also cause problems.

          4) Increase dietary cysteine

          The amino acid cysteine has also been found effective in binding copper to remove it from the brain. Common food sources of cysteine are red peppers, garlic, onions, broccoli, and Brussels sprouts. At least one meal per day should contain one or more servings of these foods.

          5) Increase zinc consumption

          The American Journal of Alzheimer?s Disease and Other Dementias, September 14, 2010, Volume 25, Number 7 reported that Alzheimer?s and Parkinson?s patients have significantly lower zinc in their blood. Zinc competes with copper in the brain, helping to eliminate excess copper. The report highlighted a 1992 study that demonstrated cognitive improvements of 80% when taking zinc for 6 months. The study suggested 25 to 50 milligrams of zinc daily.

          6) Increase dietary anti-oxidants

          The July 2004 issue of Neurological Research, Volume 26 reported that a high level of anti-oxidants were beneficial in slowing the progression of Alzheimer?s. Large doses of vitamin E were protective for the brain and nerves, and were even more effective when vitamin C and flavonoids were added. The study also reported that 600 milligrams daily of alpha-lipoic acid stabilized cognitive function in Alzheimer?s and dementia patients when taken for 11 months. Mitochondrial anti-oxidants such as CoQ10 (up to 1200 milligrams daily), ginkgo biloba, and vitamins B12, thiamine, and folate were also beneficial. Many of these anti-oxidants can be found in blueberries and cranberries.

          Additional information about Chiropractic, Naturopathy, and other forms of natural health care has been provided by Moellendorf Chiropractic Office, Ltd. at http://www.all-about-wellness.com.

          About: Dr. J G Moellendorf, DC, ND, LCP

          Dr. J G Moellendorf, DC, ND, LCP attended the University of Wisconsin?Superior where he majored in Physics and Mathematics, with a minor in art photography. While attending the University of Minnesota?Minneapolis, he assisted in research on ribosomal proteins. Completing his Chiropractic studies at Palmer College of Chiropractic in Davenport, Iowa, he graduated Cum Laude (with high honors) in 1983. He started Moellendorf Chiropractic Office, Ltd. in Sturgeon Bay, Wisconsin in 1983. In 1996, Dr. Moellendorf was awarded his Doctorate in Naturopathy from Trinity School of Natural Health. In 2001, he received Chiropractic?s most prestigious award, the honorary Legion of Chiropractic Philosophers degree, for his thesis ?The Workings of Innate Intelligence in Obsessive/Compulsive and Addictive Behaviors.? This paper was chosen for publishing in the book Philosophic Contemplations vol. 2 in 2002. In June of 2012, Dr. Moellendorf authored his first book titled Healthcare?s Best Kept Secret. Dr. Moellendorf can be contacted by phone (920) 493-2126, fax (920) 743-1145, email jgmoellendorf@itol.com, his website at http://www.all-about-wellness.com, or send a carrier pigeon to 44.84722N and 87.36416W.








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