New Oral Anticoagulants Markets (amazon) (shopzilla)

(PRWEB) June 26, 2013

New Oral Anticoagulants Markets cites in its newly published New Oral Anticoagulants Markets report that the global anticoagulants market will spike to over $ 24 billion by 2019.

Anticoagulants decrease the ability of the blood to create harmful blood clots that can ultimately lead to a heart attack or stroke. Although sometimes referred to as blood thinners, they do not actually thin the blood and only help prevent the formation of new blood clots.

Anticoagulants can be categorized into five main modalities: low molecular weight heparins (LMWHs), herapins, warfarin, direct thrombin inhibitors (DTIs) and factor Xa inhibitors. For more than 50 years and until recently, the only oral anticoagulants were vitamin K antagonists such as warfarin. Pradaxa (dabigatran), Xarelto (rivaroxaban), Eliquis (apixaban) and other new oral anticoagulants have several advantages over warfarin, including no periodical laboratory monitoring and more predictable effects with fixed doses.

The U.S. anticoagulants market, which encompasses over 60% of the global market for anticoagulants, will grow from $ 7.06 billion in 2012 to $ 15.32 billion in 2019 as it shifts from being monopolized by a single injectable anticoagulant, warfarin, to once-daily oral anticoagulants.

New Oral Anticoagulants Markets provides a thorough overview of these and other new oral anticoagulants, their approved indications, drug profiles, pharmacokinetic parameters and the respective areas of market growth.

The report also examines companies manufacturing anticoagulant equipment and supplies in the world. Companies covered include: Akers, Anthera, ARYx, AstraZeneca, Boehringer Ingelheim, Cipla, Daiichi Sankyo, Eisai, Eli Lilly, Genentech, GlaxoSmithKline, Medicines Company, Medicure, Merck, Novartis, Ortho-McNeil, Pfizer, Pharmion, Portola and Sanofi. Detailed charts with sales forecasts and marketshare data are included.

New Oral Anticoagulants Markets Table of Contents:

1. Introduction

1.1 Scope of this Report

1.2 Methodology

1.3 Executive Summary

2. An Overview of Anticoagulants

2.1 Scope of this Chapter

2.1.1 Unmet Medical Needs with Existing Anticoagulants

2.1.2 Pharmacology of Injectable Anticoagulants

2.1.3 Marketed and Registered Drugs for Anticoagulation and Related Disorders

2.2 Oral Anticoagulants

2.2.1 Potential Limitations of New Oral Anticoagulants

2.2.2 Desired Attributes of Anticoagulants

2.2.3 Comparison of New Anticoagulants

2.2.4 Bleed Rates of New Anticoagulants

3. Selected Oral Anticoagulants

3.1 Warfarin

3.1.1 Warfarins Place in Clinical Therapy

3.1.2 Drug Interaction with Warfarin

3.1.3 Warfarins Interactions with Food

3.1.4 Interactions of Warfarin with Dietary Vitamin K

3.2 Dabigatran (Pradaxa)

3.2.1 Use of Dabigatran in Particular Situations

3.2.2 Measuring the Anticoagulant Effect of Dabigatran

3.2.3 Activated Partial Thromboplastin Time (aPTT)

3.2.4 Thrombin Time (TT) and Hemoclot

3.2.5 Ecarin Clotting Time (ECT)

3.2.6 Prothrombin Time (PT) and INR

3.2.7 Measures for Overdose

3.2.8 Management of Bleeding Complications

3.2.9 For Patients Undergoing Surgical Intervention

3.2.10 For Dental Interventions

3.2.11 For Spinal Anesthesia/Epidural Anesthesia/Lumbar Puncture

3.2.12 For Patients with Acute Coronary Syndrome (ACS)

3.2.13 Cardioversion in Dabigatran Treated Patients

3.2.14 For Patients with Stroke

3.2.15 Dabigatran after Ischemic Stroke

3.2.16 Strengths and Weaknesses of Dabigatran Strengths of Dabigatran in Metabolism, Pharmacokinetics and Pharmacodynamics Weaknesses of Dabigatran in Metabolism, Pharmacokinetics and Pharmacodynamics Strengths of Dabigatran in Laboratory Monitoring Weaknesses of Dabigatran in Laboratory Monitoring Strengths of Dabigatran in Clinical Efficacy Weaknesses of Dabigatran in Clinical Efficacy Strengths of Dabigatran in Controlling Bleeding

3.2.17 Comparison of Dabigatran and Rivaroxaban in Sites of Action

3.3 Rivaroxaban (Xarelto)

3.3.1 Dosage and Administration

3.3.2 Risk of Stroke after Discontinuation in Non-Valvular Atrial Fibrillation

3.3.3 Risk of Bleeding

3.3.4 Bleeding Events in ROCKET AF Trial

3.3.5 Bleeding Events in RECORD Trial

3.3.6 Overdosage

3.3.7 Mechanism of Action

3.3.8 Comparable Efficacy of Rivaroxaban

3.3.9 Prophylaxis of Deep Vein Thrombosis

3.4 Eliquis (Apixaban)

3.4.1 AVERROES Results

3.5 Edoxaban

3.6 Betrixaban

3.7 Pipeline Agents

3.8 Comparison of Oral Anticoagulants

3.9 Heparins

3.10 Dalteparin (Fragmin)

3.11 Enoxaparin (Lovenox)

3.11.1 Indications and Usage

3.11.2 Percutaneous Coronary Revascularization Procedures

3.11.3 Use of Lovenox with Concomitant Medical Conditions Thrombocytopenia Interchangeability with Other Heparins Pregnant Women with Mechanical Prosthetic Heart Valves Laboratory Tests Pharmacodynamics Pharmacokinetics

3.12 Fondaparinux (Arixtra)

3.13 Tinzaparin (Innohep)

3.14 Semuloparin Sodium (AVE5026)

3.15 Idrabiotaparinux

3.16 Otamixaban

3.17 RB006

3.18 Reversal Agents and Antidotes

3.18.1 Vitamin K

3.18.2 Recombinant Factor VIIa

3.18.3 Prothrombin Complex Concentrates

4. A Brief Overview of Antiplatelets

4.1 Overview of this Chapter

4.1.1 Differences between Antiplatelets and Anticoagulants

4.1.2 Need for Antiplatelets

4.1.3 Side Effects of Antiplatelets

4.1.4 Choosing an Antiplatelet

4.1.5 Role of Platelets in Thrombosis

4.1.6 Inhibitors of Platelet Adhesion

4.1.7 Inhibitors of Platelet Activation Inhibitors of TXA2 Pathway Inhibitors of P2Y12 PAR-1 Inhibitors Phosphodiesterase Inhibitors

4.2 Antiplatelet Drugs

4.2.1 Aspirin

4.2.2 Aggrenox

4.2.3 Ticagrelor (Brilinta)

4.2.4 Clopidogrel (Plavix) Indications and Usage General Risk of Bleeding

4.2.5 Effient (Prasugrel)

5. Coagulation Assays

5.1 Clotting Assays

5.1.1 Chromogenic Methods

5.1.2 Prothrombin Time

5.1.3 Activated Partial Thromboplastin Time

5.1.4 Thrombin Time

5.1.5 Fibrinogen (Clauss Method)

5.1.6 Derived Fibrinogen

5.1.7 Antithrombin

5.1.8 Protein C

5.1.9 Protein S

5.1.10 Lupus Anticoagulants

5.1.11 ProC Global Assay and APC Resistance (APCR)

5.2 Influence of New Anticoagulants on Coagulation Assays

6. Disease Conditions Targeted by Anticoagulants

6.1 Cardiovascular Diseases

6.1.1 Stroke

6.1.2 Ischemic Stroke

6.1.3 Hemorragic Stroke

6.1.4 Subarachnoid Hemorrage

6.1.5 Global Incidence and Prevalence of Stroke

6.1.6 Incidence of Stroke in the U.S.

6.1.7 Mortality from Heart Disease and Stroke i

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