A Cross-Sectional Analysis on Deficiency of Choline, a Nutrient, Results in an Important Finding for Postmenopausal Women (amazon) (shopzilla)

Miami, Florida (PRWEB) February 22, 2012

The result of a newly published study suggests that postmenopausal women, with an inadequate choline diet, are at higher risk of fibrosis. Nutri-Med Logic Corp adds that in 1998, the Food and Nutrition Board of the Institute of Medicine established a dietary reference intake (DRI) of choline for females based on age, but only from 0 month up to adulthood. The only other distinction, in adult females, was for pregnant or lactating mothers. The US Institute of Medicine did not consider pre or postmenopausal age as criteria for setting a corresponding choline intake.

The John Hopkins study encompassed 644 subject, which were grouped into children of 9-13 years old, males more than 13 years old, premenopausal women more than 18 years of age and postmenopausal women, taking into account the adequate choline intake as set by US institute of Medicine; Choline deficiency was defined to be at less than 50% of the adequate intake.

The result of the analysis suggests that postmenopausal women, with fatty liver, having a choline deficient diet had worse fibrosis.

Nutri-Med Logic Corp adds that this new study correctly opens the discussion, as to whether the Choline adequate intake for females needs to be further examined and additional classification would be appropriate for adult females, to-wit, considering the menopausal stage as a new category and same to be irrespective of the liver health of pre or postmenopausal women.

It is well established that premenopausal women might be resistant to choline deficiency due to their production of estrogen, which induces synthesis of choline via the PEMT enzyme (FASEB J. 2007 Aug;21(10):2622-32).

However, given the fact that estrogen levels begin to drop right before, during and after the menopause, further studies might be needed for the adequate choline intake in this category of adult females.

While this study took into account the fatty liver (non-alcoholic) as a factor in the severity of fibrosis but it is with a doubt that deficiency of choline, by itself, might be a cause of non-alcoholic fatty liver, in the first place.

Obviously, non-alcoholic fatty liver is associated to variety of factors, but choline deficiency remains as one of the front-runners. A search of PubMed database on choline deficient diet and studies on choline and fatty liver dates back to 1934.

Furthermore, due to estrogen, physiologically premenopausal women would have a lower choline requirement than men, but with a loss of estrogen at menopausal stage, when taking into account the result of this study, the adequate choline intake for postmenopausal women deserves a new review.

In conclusion, Nutri-Med Logic Corp agrees with this important study and adds that it might be appropriate to revisit the choline requirement for adult females and re-determine if pre or postmenopausal women would require a separate adequate intake classification.

Nutri-Med Logic Corp is the producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp is also the producer of the Natural, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for decades;

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on other potential benefits Poly-Enyl-Phosphatidylcholine and anti-inflammatory nutrients such as Omega-3 and What Is Omega-3 Good For.

Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.


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    Steroid Injection Linked with Significant Bone Loss in Postmenopausal Women Treated for Back Pain (amazon) (shopzilla)

    DETROIT (PRWEB) November 30, 2012

    Postmenopausal women suffered significant bone density loss in their hip after they were treated with an epidural steroid injection for back pain relief, according to a Henry Ford Hospital study

    Bone density loss after six months was six times greater when compared to the typical bone density loss seen in a year in a postmenopausal woman who doesnt receive steroid injection, researchers say.

    Shlomo Mandel, M.D., a Henry Ford orthopedic physician and the studys lead author, says physicians should exercise caution prescribing an epidural steroid for select patients, suggesting that multiple injections may compromise bone strength.

    The findings of our study suggest that epidural steroid injections for back pain relief should be approached cautiously in patients at risk for bone fragility, Dr. Mandel says. Physicians who do prescribe them should consider measures that optimize bone health such as calcium and vitamin D supplements and exercise as part of their patients treatment plan.

    The study will be published in the Dec. 1 edition of Spine http://journals.lww.com/spinejournal/pages/default.aspx

    Back pain is one of the most common medical conditions in the United States, affecting 8 out of 10 people at some point during their lives. As people age, their spine ages with them, causing degenerative changes in the spine.

    Patients are typically treated with anti-inflammatory drugs and physical therapy. If symptoms persist, an epidural steroid is often prescribed to alleviate pain and improve function. However, steroid use has been linked to diminished bone quality.

    In the observational study, Henry Ford sought to evaluate whether steroid injections used for treating lumbar stenosis, increased the risk of bone loss in postmenopausal women. Lumbar stenosis is an abnormal narrowing of the spine canal. Twenty-eight patients, aged 65 and older and treated between 2007-2010, were evaluated for bone loss using bone density testing and serum biochemical markers prior to receiving an injection, then at three- and six-month intervals.

    The bone loss data was compared to bone loss data for postmenopausal women who hadnt been treated with an epidural injection.

    Patients receiving multiple steroid injections with a history of steroid exposure may be especially susceptible to compromised bone strength, Dr. Mandel says.

    The study was funded by Henry Ford Hospital.


    EDITORS NOTE: Henry Ford did not use the steroid injection medication at the center of the current meningitis outbreak.

    CONTACT: David Olejarz



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