A New Study Suggests Certain Nutrients May Offer a Healthy Intervention In Premature Aging of Lungs (amazon) (shopzilla)

(PRWEB) January 22, 2012

A recently published study opens the discussion of the importance of nutrients as a therapeutic vehicle in lung diseases, such as COPD and Emphysema. Expanding on this study, Nutri-Med Logic Corp states that, while polyphenols in this new study are correctly suggested to retain potent anti-oxidant properties, capable of activating certain genes associated with aging, R-alpha Lipoic, an endogenous anti-oxidant, also retains similar suggested potent anti-oxidant properties, capable of interfering with premature cellular aging.

According to American Society for Clinical Nutrition (Proceedings of The International Conference on Polyphenols and Health), polyphenols are antioxidants, and since 1995 they have received more reviews and interest from nutritionists than antioxidant vitamins, carotenoids or minerals. (1)

In 2010, the Department of Environmental Medicine’s Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, proposed that polyhenols, aside from having anti-oxidant properties, also, possess the potential ability to regulate metabolism, stress resistance, cellular survival, and cellular aging. (2)

In this recent study, University of Rochester Medical Center, states that COPD is, also, inflammaging (inflammatory disease associated with aging) and, further, since polyphenols possess the potential ability to regulate inflammation, due to their anti-oxidant and anti-inflammatory nature, promote cellular resistance to premature death via activating Sirt-1 (a gene associated with regulation of cellular aging), polyphenols offer promising therapeutic intervention for lung health.

Notable polyphenols are resveratrol, curcumin and catechins, found in red wine, turmeric and green-tea, respectively.

Not only the University of Rochester Medical Center but also many other equally prestigious institutes have suggested the potential benefits from nutrients such as polyphenols, due to their antioxidant, anti-inflammatory and anti-premature cellular aging potentials.

One other equally important nutrient is R-Alpha Lipoic, which has anti-oxidant properties that could surpass polyphenols, due to its hydrophilic and lipophilic ability (water and fat soluble), as well as its potential ability to neutralize free radicals in mitochondria (cellular energy plant).

Alpha Lipoic was used by Dr. Burton Burkson, The FDA principal investigator of Lipoic Acid for last 23 years, in the treatment of a patient with pancreatic cancer and liver metastases. Dr. Burkson credits Lipoic Acid for its ability to moderate NF-kB, a master switch of inflammation. As a parallel comparison, the recent study also suggests moderation of NF-kB by polyphenols.

Additionally the anti-aging properties of R-Alpha Lipoic acid was a component of supplements that got the attention of the National Cancer Institute (NCI) Division of Cancer Biology (DCB) as a popular combination of anti-aging and vitality formula, as reported by National Toxicology program, National Institute of Environmental Health Sciences.

It has been suggested that dietary supplementation of R-Alpha Lipoic Acid (also known as R- Lipoic Acid), increases the production, as well as the cellular concentration, of glutathione, which decrease by age. Glutathione is perhaps the most potent internal anti-oxidant and its decline shifts the body toward oxidative stress and its inevitable consequences of cellular aging.

In Conclusion, Nutri-Med Logic Corp agrees with this recent study regarding the benefits of polyphenols. However, Nutri-Med Logic Corp adds that R-Alpha Lipoic is equally important as an endogenous anti-oxidant, and a vital co-enzyme in the production of energy, which a plethora of studies have suggested. Also, it is valuable for its multi-faceted benefits.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years.

Nutri-Med Logic Corp is also producer of a Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years;

Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above and below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. American Journal of Clinical Nutrition, Vol. 81, No. 1, 215S-217S, January 2005

2. Arch Biochem Biophys. 2010 Sep 1;501(1):79-90

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    New Study on Oxidative Stress Provides Insights to Premature Aging, Diabetes, Atherosclerosis, Hypertension and Neurodegenerative Diseases (amazon) (shopzilla)

    Miami, FL (PRWEB) February 17, 2012

    A newly published study, adopting the thinning of skin layers as a measure of normal or premature aging and the development of degenerative disease, states that in animal models proper anti-oxidant defense lead to normal skin aging, whereas deficiency in the anti-oxidant defense resulted in premature aging. Nutri-Med Logic Corp adds that an imbalance in the anti-oxidant defense inevitably involves the immune system and, thus, shifting its homeostasis. Accordingly, any therapeutic intervention needs to incorporate anti-inflammatory nutrients, as well.

    According the study, at ideal levels, ROS play essential roles as regulatory mediators in signaling or defense processes, including the promotion of angiogenesis (blood vessel formation), erythropoietin (red blood cell) production and the destruction of bacteria and other foreign substances by immune system.

    ROS is regulated by cellular anti-oxidant defense system, one of which is Superoxide Dismutase (SOD). Lower cellular levels of SOD gives rise to excessive Reactive Oxygen Species concentration. In another word, development of oxidative stress and according to this study, a growing body of evidence suggests its definitive role in premature aging and a host of human diseases ranging from diabetes, atherosclerosis, hypertension, cardiovascular diseases, neurodegenerative diseases up to cancer (DNA damage).

    Nutri-Med Logic Corp states that while increasing SOD might not be effectively attainable through diet, but the concentration of an equally important internal anti-oxidant, R-Alpha Lipoic, could very well be attained through its dietary supplementation.

    Both R-Alpha Lipoic and SOD are found in the mitochondria, where metabolism of glucose gives rise to the production of Reactive Oxygen Species.

    Application of R-Alpha Lipoic has conclusively shown that in presence of R-Alpha Lipoic, there is reduced requirement for SOD, by the human body, indicating the importance of R-Alpha Lipoic as a key anti-oxidant nutrient. (1)

    Other studies have shown that SOD presents anti-inflammatory properties, more specifically in studies relating to inflammatory Bowel Disease. (2)

    Inflammation is an immune mechanism and its dysregulation is not limited to Inflammatory Bowel Disease, rather it is implicated in the same spectrum of diseases as the oxidative stress, including but limited to per-mature cellular aging, diabetes, atherosclerosis, hypertension, cardiovascular diseases, neurodegenerative diseases up to cancer.

    While SOD has anti-inflammatory properties but it is not the mechanism, by which the human body resolves the inflammation. The human body resolves inflammation in two principal manners, one of which is through derivatives of Omega-3 fatty acids. The human body is incapable of producing Omega-3, thus it must be supplied through diet.

    While addition of R-Alpha Lipoic is a valuable nutritional support in improving the anti-oxidant defense (redox homeostasis), contemporaneous incorporation of the most powerful anti-inflammatory nutrient (Omega-3) would improve the homeostasis of the immune system (inflammation).

    In conclusion, Nutri-Med Logic Corp agrees with this important new study but adds that regulation of inflammation is equally as important, in opposing the development of age-related disease and cellular premature aging, as the regulated anti-oxidant defense.

    Nutri-Med Logic Corp. is a producer dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years;

    Nutri-Med Logic Corp is also the producer of the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

    Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

    Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on the potential benefits of R-Alpha Lipoic and benefits of Omega-3 anti-inflammatory nutrient and What Is Omega-3 Good For.

    Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

    It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to treatment or cure.

    (1) J Brachial Plex Peripher Nerve Inj. 2010; 5: 15

    (2) J Leukoc Biol. 2004 Sep;76(3):537-44

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      Improving the Regulation of Energy Expenditure May Reduce the Risk of Cardiovascular Diseases and Avoid Pre-Mature Cellular Aging (amazon) (shopzilla)

      Miami, FL (PRWEB) February 28, 2012

      A newly published study suggests, in animal models, an increased activity (expression) of a regulator of metabolism, PGC-1 Alpha, may improve pre-mature cellular aging. Nutri-Med Logic Corp, agreeing with this notable study, adds that credible research and evidence has pointed to R-Alpha Lipoic, a nutrient and a vital co-enzyme in the production of energy, as a viable mean to improve the activities of this regulator.

      According to this study, by Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL, aging increases our vulnerability to muscle degeneration (Sarcopenia), as well as cardiovascular diseases and that the accumulated alteration (mutation) in mitochondrial (cellular energy plant) DNA caused its dysfunction leading to potentially shorter lifespan.

      According to the University of Miami study, the increased expression of PGC-1 Alpha, a regulator of metabolism, while improved the mitochondrial function but did not reverse the accumulated mutation in mitochondrial DNA, rather it caused a small increase in its mutation. Nonetheless, the increased expression of muscle PGC-1 Alpha improved some premature aging phenotypes.

      Suffices to say that increasing the function or capacity of mitochondria (biogenesis) results in the production of additional reactive oxygen species (oxidative stress) and the increased oxidative stress would be a contributing factor for the added mutation, in the abundance of mitochondria, as well as the copy number and integrity of mitochondrial DNA in human cells. (1)

      Amongst mitochondrial anti-oxidant molecules, mitochondrial glutathione not only acts as key anti-oxidant defense against reactive oxygen species but also acts as a detoxifying enzyme, counteracting a variety of free radicals such as hydrogen peroxide, lipid hydroperoxides and xenobiotics, as well as being a co-factor for enzymes glutathione peroxidase or glutathione-S-transferase. (2)

      In addition and according to The Department of Internal Medicine of University of Miami, the cellular Reduction-Oxidation (redox) is regulated by three systems, two of which are also regulated by glutathione. (3)

      Overwhelming number of institutes, including the prestigious Linus Pauling Institute, have determined that Lipoic Acid (also known as R-Alpha Lipoic Acid) increases the synthesis of glutathione in the human cells.

      Moreover and according to USDA/ARS Childrens Nutrition Research Center, in aged animals, the metabolic action of R-Alpha Lipoic is mediated through activating a cellular energy sensor (AMPK) that can regulate PGC-1 Alpha, a metabolic regulator. (4)

      The USDA/ARS study suggests that, in animal studies, R-Alpha Lipoic Acid improves skeletal muscle energy metabolism (PGC-1 Alpha).

      In conclusion, Nutri-Med Logic Corp agrees with this study and adds that R-Alpha Lipoic Acid, a nutrient and a vital co-enzyme in the production of cellular energy, offers unique health benefits such as being a potent anti-oxidant by itself, increasing the glutathione levels and most importantly improving the energy homeostasis.

      Nutri-Med Logic Corp is a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, a potent anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades.

      Nutri-Med Logic Corp is also the producer of the Natural, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

      Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

      Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on other potential benefits of R-Alpha Lipoic Acid and anti-inflammatory nutrients such as Omega-3 and What Is Omega-3.

      Nutri-Med Logic’s products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

      It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

      1. Int J Biochem Cell Biol. 2005 Apr;37(4):822-34.

      2. Antioxidants & Redox Signaling, Volume 11, Number 11, 2009

      3. Drugs. 2011 Jul 30;71(11):1385-96

      4. Metabolism. 2010 July; 59(7): 967976.

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